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Dehydrocholic acid

CAT: 0804-HY-B1393-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-B1393-01Size:1 g
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Description
Dehydrocholic acid (Dehydrocholate) is an orally active hydrocholeretic agent. Dehydrocholic acid modulates Autophagy, reduces serum amylase and lipase levels. Dehydrocholic acid has the effects of promoting choleretic function, protecting the liver, reducing pancreatic damage, and regulating cholesterol metabolism. Dehydrocholic acid can be used in the study of acute biliary pancreatitis and obstructive jaundice[1][2][3][4][5].
CAS Number
81-23-2
Product Name Alternative
Dehydrocholate
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Amylases; Autophagy; Lipase
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Dehydrocholic-acid.html
Purity
99.92
Solubility
DMSO : 25 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
C[C@H](CCC(O)=O)[C@H]([C@]12C)CC[C@@]1([H])[C@]3([H])C(C[C@]4([H])CC(CC[C@]4(C)[C@@]3([H])CC2=O)=O)=O
Molecular Formula
C24H34O5
Molecular Weight
402.52
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhang X, et al. Dehydrocholic Acid Ameliorates Sodium Taurocholate-Induced Acute Biliary Pancreatitis in Mice. Biol Pharm Bull. 2020;43 (6) :985-993.|[2]Yousef IM, et al. Influence of dehydrocholic acid on the secretion of bile acids and biliary lipids in rats. Digestion. 1990;45 (1) :40-51.|[3]Ratan J, et al. A controlled trial of choleretic and hepatoprotective actions of Livzon and dehydrocholic acid in a model of obstructive jaundice in albino rats. Tohoku J Exp Med. 1997 Jan;181 (1) :161-6.|[4]UCHIDA K, et al. EFFECTS OF SODIUM URSODEOXYCHOLATE, HYODEOXY-CHOLATE AND DEHYDROCHOLATE ON CHOLESTEROL AND BILE ACID METABOLISM IN RATS. Journal of Pharmacobio-Dynamics, 1983, 6 (5) : 346-357.|[5]Magos L, et al. The effect of phenobarbital and sodium dehydrocholate on the biliary excretion of methylmercury in the rat. Toxicology and Applied Pharmacology, 1974, 30 (1) : 1-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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