AMPK alpha2 Polyclonal Antibody

CAT: 0763-D-AB-10161L-01Size: 25 µLDry Ice: NoHazardous: No

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CAT#:0763-D-AB-10161L-01Size:25 µL

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Background

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK) . AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.

Abbreviation

AMPK

UniProt

Q09137

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant Rat Ampk2 protein expressed by E.coli

Target

5'-AMP-activated protein kinase catalytic subunit alpha-2; AAPK2; ACACA kinase; Acetyl-CoA carboxylase kinase; AMPK alpha 2 chain; AMPK subunit alpha-2; AMPK2; AMPKa2; AMPKalpha2; HMGCR kinase; Hydroxymethylglutaryl-CoA reductase kinase; PRKAA; PRKAA2; Protein kinase AMP activated alpha 2 catalytic subunit; Protein kinase AMP activated catalytic subunit alpha 2

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC; IF

Field of Research

Cancer; Cardiovascular; Metabolism; Signal Transduction

Purification

Antigen Affinity Purification

Concentration

1 mg/mL

Dilution

WB 1:500-1:1000; IHC 1:100-1:200; IF 1:100-1:400

Buffer

PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

62 kDa

Observed Molecular Weight

62 kDa

Isotype

IgG

UniProtKB · Q09137

5'-AMP-activated protein kinase catalytic subunit alpha-2

AAPK2_RAT · Rattus norvegicus

View on UniProt ↗

Primary accession: Q09137
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: Prkaa2
Protein existence: 1: Evidence at protein level
Organism: Rattus norvegicus (Rat)
Taxonomy ID: 10116
Alternative names: AMPK subunit alpha-2
EC number: 2.7.11.1
Processing: —
Secondary accessions: —

Protein keywords

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Biological process

AutophagyBiological rhythmsCholesterol biosynthesisCholesterol metabolismFatty acid biosynthesisFatty acid metabolismLipid biosynthesisLipid metabolismSteroid biosynthesisSteroid metabolismSterol biosynthesisSterol metabolismTranscriptionTranscription regulationWnt signaling pathway

Molecular function

Chromatin regulatorKinaseSerine/threonine-protein kinaseTransferase

Cellular component

CytoplasmEndosomeNucleus

Technical term

Direct protein sequencingReference proteome

PTM

PhosphoproteinUbl conjugation

Product Datasheet

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