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Decapeptide-12

CAT: 0804-HY-P0096-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P0096-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Decapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with C-terminal residue of tyrosinase (Kd: 61.1 μM) . Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC50: 40 μM) . Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation [1][2][3].
CAS Number
137665-91-9
UNSPSC
12352209
Target
Sirtuin; Tyrosinase
Type
Peptides
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/decapeptide-12.html
Purity
99.95
Solubility
H2O : ≥ 100 mg/mL
Smiles
[Y][R]S[R]([Y]=S=S=[W][Y])[K]
Molecular Formula
C65H90N18O17
Molecular Weight
1395.52
References & Citations
[1]Anan Abu Ubeid, et al. Short-sequence oligopeptides with inhibitory activity against mushroom and human tyrosinase. J Invest Dermatol. 2009 Sep;129 (9) :2242-9. |[2]Akihito Ochiai, et al. New tyrosinase inhibitory decapeptide: Molecular insights into the role of tyrosine residues. J Biosci Bioeng. 2016 Jun;121 (6) :607-613. |[3]Basil M H, et al. Tyrosinase inhibitors with potent anti-senescence activity in human neonatal keratinocyte progenitors. J Dermatol Surg Res Ther, 2019, 2019: 30-39.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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