Decapeptide-12

• Description:

  Decapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with C-terminal residue of tyrosinase (Kd: 61.1 μM) . Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC50: 40 μM) . Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation [1][2][3].

• UNSPSC:

  12352209

• Target:

  Sirtuin; Tyrosinase

• Type:

  Peptides

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Endocrinology; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/decapeptide-12.html

• Purity:

  99.95

• Solubility:

  H2O : ≥ 100 mg/mL

• Smiles:

  [Y][R]S[R]([Y]=S=S=[W][Y])[K]

• Molecular Formula:

  C65H90N18O17

• Molecular Weight:

  1395.52

• References & Citations:

  [1]Anan Abu Ubeid, et al. Short-sequence oligopeptides with inhibitory activity against mushroom and human tyrosinase. J Invest Dermatol. 2009 Sep;129 (9) :2242-9. |[2]Akihito Ochiai, et al. New tyrosinase inhibitory decapeptide: Molecular insights into the role of tyrosine residues. J Biosci Bioeng. 2016 Jun;121 (6) :607-613. |[3]Basil M H, et al. Tyrosinase inhibitors with potent anti-senescence activity in human neonatal keratinocyte progenitors. J Dermatol Surg Res Ther, 2019, 2019: 30-39.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  [137665-91-9]