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Mouse Tenascin C Antibody

CAT: 0013-GTR17701449Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR17701449Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mouse monoclonal to Tenascin C. Tenascin is a high molecular weight, multifunctional, extracellular matrix glycoprotein expressed in association with mesenchymal-epithelial interactions during development. It has been described under a variety of names, i.e. cytotactin, hexabrachion protein, J1, myotendinous antigen and glioma mesenchymal extracellular matrix. In undifferentiated tumors it is also detectable in the neovasculature and stroma. The tenascin molecule is a disulfide-linked hexamer. The expression of tenascin is associated with development and growth, both normal and pathological, whereas the distribution in normal adult tissue is restricted. For example, this extracellular matrix protein is implicated in guidance of migrating neurons as well as axons during neural development as well as neuronal regeneration. In in vitro studies it promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. The cellular ligands for tenascin include integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.
UniProt
P24821
Reactivity
Human
Clonality
Monoclonal
Clone
T2H5
Conjugation
Unconjugated
Source
T2H5 is a mouse monoclonal IgG1 antibody derived by fusion of mouse myeloma cells with spleen cells from a BALB/c mouse immunized with full length native tenascin protein purified from a homogenate of a human mammary tumour specimen.
Field of Research
Cancer Biology, Cell Biology, Neuroscience
Form
Each vial contains 100 μl 1 mg/ml purified monoclonal antibody in PBS containing 0.09% sodium azide.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
ICC, IHC, IP, WB
Host or Source
Mouse
Isotype
IgG1

UniProtKB · P24821

Tenascin

TENA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P24821
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TNC
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
TN
EC number
—
Processing
Precursor
Secondary accessions
C9IYT7, C9J575, C9J6D9, C9J848, Q14583, Q15567, Q5T7S3
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesion

Domain

Coiled coilEGF-like domainRepeatSignal

Disease

DeafnessDisease variantNon-syndromic deafness

PTM

Disulfide bondGlycoproteinPhosphoproteinProteoglycan

Cellular component

Extracellular matrixSecreted

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Alternative Products

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