Adipokinetic hormone II (Locusta migratoria)

• UNSPSC Description:

  Adipokinetic hormone II (Locusta migratoria) (Lom-AKH-II) is a insect adipokinetic hormone (AKH), enhances fat body cAMP levels in vitro. Insect adipokinetic hormones (AKHs) controls flight-directed mobilization of carbohydrate and lipid from fat body stores, which depends on AKH receptor(s) coupling to cAMP formation and glycogen phosphorylase activation via the stimulatory guanine nucleotide-binding protein (Gs)[1][3].

• Target Antigen:

  Endogenous Metabolite

• Type:

  Peptides

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/adipokinetic-hormone-ii-locusta-migratoria.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C([C@H]1NC(CC1)=O)N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CO)C(N[C@@H](C)C(NCC(N[C@H](C(N)=O)CC3=CNC4=CC=CC=C34)=O)=O)=O)=O)=O)=O

• Molecular Weight:

  903.98

• References & Citations:

  [1]Oudejans RC, et al. Locust adipokinetic hormones: carrier-independent transport and differential inactivation at physiological concentrations during rest and flight. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8654-9. |[2]Gautam UK, et al. Adipokinetic hormone promotes infection with entomopathogenic fungus Isaria fumosorosea in the cockroach Periplaneta americana. Comp Biochem Physiol C Toxicol Pharmacol. 2020 Mar;229:108677. |[3]Vroemen SF, et al. Stimulation of glycogenolysis by three locust adipokinetic hormones involves Gs and cAMP. Mol Cell Endocrinol. 1995 Feb;107(2):165-71. |[4]Goldsworthy, et al. The relative potencies of two known locust adipokinetic hormones. 1986;32(1):95-101.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  98968-94-6