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Glycochenodeoxycholic acid

CAT: 0804-HY-N2334-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2334-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC) . Glycochenodeoxycholic acid is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC) [1][2][3][4].
CAS Number
640-79-9
Product Name Alternative
Chenodeoxycholylglycine
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; BCL6; Caspase; Endogenous Metabolite; Interleukin Related; STAT
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Glycochenodeoxycholic_acid.html
Purity
99.84
Solubility
DMSO : 100 mg/mL (ultrasonic) |Methanol : 100 mg/mL (ultrasonic)
Smiles
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(NCC(O)=O)=O)([H])[C@@]3([H])[C@]([C@@]4([C@](C[C@H](O)CC4)([H])C[C@H]3O)C)([H])CC1
Molecular Formula
C26H43NO5
Molecular Weight
449.62
Precautions
H302, H315, H319, H335
References & Citations
[1]Gonzalez B, et al. Glycochenodeoxycholic acid (GCDC) induced hepatocyte apoptosis is associated with early modulation of intracellular PKC activity. Mol Cell Biochem. 2000 Apr;207 (1-2) :19-27.|[2]Lan W, et al. Glycochenodeoxycholic acid impairs transcription factor E3 -dependent autophagy-lysosome machinery by disrupting reactive oxygen species homeostasis in L02 cells[J]. Toxicol Lett. 2020 Oct 1;331:11-21. |[3]Wang A, et al. Glycochenodeoxycholic Acid Does Not Increase Transforming Growth Factor-Beta Expression in Bile Duct Epithelial Cells or Collagen Synthesis in Myofibroblasts[J]. J Clin Exp Hepatol. 2017 Dec;7 (4) :316-320.|[4]Shi C, et al. Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells[J]. Aging (Albany NY) . 2020 Aug 3;12 (15) :15546-15555.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite; Microbial Metabolite
Citation 01
Adv Sci (Weinh) . 2025 Feb 3:e2411719.|Biomolecules. 2025 Jun 28;15 (7) :943. |Discov Oncol. 2023 Jan 11;14 (1) :4.|SSRN. 2022 Jan 26.|Hepatol Int. 2024 Jun;18 (3) :1040-1052.

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