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NIAD-4

CAT: 0013-GTR19304826-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19304826-02Size:25 mg
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Description
NIAD-4 is a near-infrared fluorescent probe with high affinity for amyloid-beta (Ki=10 nM) and blood-brain barrier permeability. It enables in vivo optical imaging of Aβ plaques in Alzheimer's disease models and is used for both in vitro binding assays and in vivo CNS imaging studies, with absorption peaks at 475–480 nm.
CAS Number
868592-56-7
Product Name Alternative
NIAD 4, NIAD4, NIAD-4
Field of Research
Neuroscience
Purity
99.66% (May vary between batches)
Solubility
DMSO:PBS (pH 7.2) (1:2) :0.3 mg/mL (0.9 mM) ; DMSO:20 mg/mL (59.81 mM) ; Ethanol:0.2 mg/mL (0.6 mM) ; DMF:25 mg/mL (74.76 mM)
Molecular Weight
334.42
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Niad-4
CAS Number868592-56-7
PubChem CID9639427
IUPAC Name2-[[5-[5-(4-hydroxyphenyl)thiophen-2-yl]thiophen-2-yl]methylidene]propanedinitrile
Molecular FormulaC18H10N2OS2
Molecular Weight334.4
XLogP4.4
Topological Polar Surface Area124
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count23
Formal Charge0
Complexity532
SMILES
C1=CC(=CC=C1C2=CC=C(S2)C3=CC=C(S3)C=C(C#N)C#N)O
InChI
InChI=1S/C18H10N2OS2/c19-10-12(11-20)9-15-5-6-17(22-15)18-8-7-16(23-18)13-1-3-14(21)4-2-13/h1-9,21H
InChIKey
KLFRZDOQQDHVSS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Niad-4
CAS: 868592-56-7
CID: 9639427
Formula: C18H10N2OS2
MW: 334.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight334.4
XLogP34.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass334.02345529
Monoisotopic Mass334.02345529
Topological Polar Surface Area124 Ų
Heavy Atom Count23
Formal Charge0
Complexity532
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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