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Cytostatin

CAT: 0804-HY-113612-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113612-01Size:25 mg
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Description
Cytostatin is an effective and selective protein phosphatase 2A (PP2A) inhibitor with an IC50 value of 210 nM. Cytostatin exhibits anti-metastatic properties, good antitumor activity, and can induce apoptosis. Cytostatin can also prevent the adhesion of B16 melanoma cells to components of the extracellular matrix (laminin and collagen) . Cytostatin belongs to the family of natural product fosriecin[1][2][3][4].
CAS Number
682329-63-1
Product Name Alternative
BYK61359
UNSPSC
12352005
Target
Apoptosis; Phosphatase
Type
Natural Products
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cytostatin.html
Solubility
10 mM in DMSO
Smiles
O=C1C=C[C@H](C)[C@H]([C@@H](C)CC[C@H](OP(O)(O)=O)[C@@H](C)[C@@H](O)/C=C\C=C/C=C/C)O1
Molecular Formula
C21H33O7P
Molecular Weight
428.46
References & Citations
[1]Lawhorn BG, et al. Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition. J Am Chem Soc. 2006;128 (51) :16720-16732. |[2]Kawada M, et al. Cytostatin, an inhibitor of cell adhesion to extracellular matrix, selectively inhibits protein phosphatase 2A. Biochim Biophys Acta. 1999;1452 (2) :209-217. |[3]Kawada M, et al. Differential induction of apoptosis in B16 melanoma and EL-4 lymphoma cells by cytostatin and bactobolin. Jpn J Cancer Res. 1999;90 (2) :219-225.|[4]Bialy L, et al. Total synthesis and biological evaluation of the protein phosphatase 2A inhibitor cytostatin and analogues. Chemistry. 2004;10 (11) :2759-2780.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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207143Cytostatin (5,6-Dihydro-6- (6-hydroxy-1,5-dimethyl-4- (phosphonooxy) -7,9,11-tridecatrienyl) -5-methyl-2H-pyran-2-one)

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