Cytostatin

• Target :

  Others|||Apoptosis|||Phosphatase

• Related Pathways :

  Others|||Metabolism|||Apoptosis

• Bioactivity :

  Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 ?g/ml, respectively) and B16 cells metastatic activity in mice. It induces apoptosis of FS3 mouse fibrosarcoma cells (IC50 = 3.1 ?g/ml) . Cytostatin potently and selectively inhibits protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), while having no effect against PP1, PP2B, or PP5.

• Smiles :

  [H][C@]1(OC(=O)C=C[C@@H]1C)[C@@H](C)CC[C@H](OP(O)(O)=O)[C@@H](C)[C@@H](O)\C=C/C=C\C=C\C|c:5|

• Molecular Formula :

  C21H33O7P

• Molecular Weight :

  428.462

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  682329-63-1