Products for Research Use Only
RegisterLogin

Quinocetone

CAT: 0804-HY-123581-01Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-123581-01Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Quinocetone is an orally active animal feed additive used to increase the meat production of livestock and poultry. Quinocetone exhibits antibacterial activity against a variety of pathogenic microorganisms. Quinocetone exhibits tissue-specific (liver, lymphocyte) toxicity. Quinocetone induces autophagy in cells through the ATF6/DAPK1 pathway. Quinocetone activates the NF-κB and iNOS pathways, leading to cell apoptosis, hepatocyte vacuolar degeneration and fibrosis. Quinocetone can inhibit Nrf2/HO-1 and induce the generation of reactive oxygen species (ROS), leading to oxidative stress and DNA damage[1][2][3][4].
CAS Number
81810-66-4
UNSPSC
12352005
Hazard Statement
H315, H319, H335, H341
Target
Antibiotic; Apoptosis; ATF6; Autophagy; Bacterial; DAPK; Heme Oxygenase (HO) ; Keap1-Nrf2; NF-κB; NO Synthase; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/quinocetone.html
Purity
98.00
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C)[N+]([O-])=C2C=CC=CC2=[N+]1[O-])/C=C/C3=CC=CC=C3
Molecular Formula
C18H14N2O3
Molecular Weight
306.32
Precautions
H315, H319, H335, H341
References & Citations
[1]Zhao Y, et al. In vitro antimicrobial activities of animal-used quinoxaline 1,4-di-N-oxides against mycobacteria, mycoplasma and fungi. BMC Vet Res. 2016 Sep 6;12 (1) :186. |[2]Zhou Y, et al. Quinocetone triggered ER stress-induced autophagy via ATF6/DAPK1-modulated mAtg9a trafficking. Cell Biol Toxicol. 2016 Apr;32 (2) :141-52. |[3]Yang W, et al. Quinocetone triggers oxidative stress and induces cytotoxicity and genotoxicity in human peripheral lymphocytes of both genders. J Sci Food Agric. 2013 Apr;93 (6) :1317-25.|[4]Yu M, et al. Quinocetone-induced Nrf2/HO-1 pathway suppression aggravates hepatocyte damage of Sprague-Dawley rats. Food Chem Toxicol. 2014 Jul;69:210-9. doi: 10.1016/j.fct.2014.04.026. Epub 2014 Apr 30. PMID: 24795230.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DAPK1; HO-1; iNOS; NF-κB

Alternative Products

CatalogName
MBS3611606-01Quinocetone
463379-01Quinocetone-d5
GTR19150795Quinocetone-BSA conj.
GTR19150700Quinocetone-OVA conj.
GTR19150889Quinocetone-KLH conj.

Popular Products