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β-Amyrin

CAT: 0804-HY-N2922-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2922-01Size:1 mg
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Description
β-Amyrin shows effectively counteract amyloid β (Aβ) -induced impairment of long-term potentiation (LTP) . β-Amyrin is a promising candidate for Alzheimer's disease (AD) research. β-Amyrin exhibits anti-inflammatory effects, protective activity against pulmonary fibrosis, and notable antibacterial capabilities. β-Amyrin is an orally active natural triterpenoid compound[1][2][3][4].
CAS Number
559-70-6
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Amyloid-β; NF-κB
Type
Natural Products
Related Pathways
Neuronal Signaling; NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/beta-amyrin.html
Purity
99.95
Solubility
Ethanol : 5 mg/mL (ultrasonic)
Smiles
CC1(C)[C@@H](O)CC[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])CC(C)(C)CC[C@@](C)5CC[C@](C)4[C@@](C)3CC[C@@]12[H]
Molecular Formula
C30H50O
Molecular Weight
426.72
Precautions
H302, H315, H319, H335
References & Citations
[1]Park HJ, et al. β-Amyrin Ameliorates Alzheimer's Disease-Like Aberrant Synaptic Plasticity in the Mouse Hippocampus. Biomol Ther (Seoul) . 2019 Jul 30. |[2]Krishnan K, et al. Anti-inflammatory potential of β-amyrin, a triterpenoid isolated from Costus igneus. Inflammopharmacology. 2014 Dec;22 (6) :373-85. |[3] Cai Z, Liu J, et al. β-Amyrin ameliorates pulmonary fibrosis by inhibiting inflammatory response and oxidative stress in mice. Pak J Pharm Sci. 2023 Mar;36 (2) :431-436.|[4]Han G, et al. Antibacterial Mode of Action of β-Amyrin Promotes Apoptosis-Like Death in Escherichia coli by Producing Reactive Oxygen Species. J Microbiol Biotechnol. 2022 Dec 28;32 (12) :1547-1552. |[5]Ching J, et al. Quantification of α- and β-amyrin in rat plasma by gas chromatography-mass spectrometry: application to preclinical pharmacokinetic study. J Mass Spectrom. 2011 May;46 (5) :457-64.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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