LTV-1

• Description:

  LTV-1 is a potent lymphoid tyrosine phosphatase (LYP) inhibitor in T cells with an IC50 of 508 nM. LTV-1 has the potential for autoimmunity treatment[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H400

• Target:

  Phosphatase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/LTV-1.html

• Purity:

  98.0

• Solubility:

  DMSO : 22.73 mg/mL (ultrasonic)

• Smiles:

  O=C (O) C1=CC=CC (COC2=CC=C (/C=C (C (N3C4=CC=CC=C4C) =O) \C (NC3=S) =O) C=C2) =C1

• Molecular Formula:

  C26H20N2O5S

• Molecular Weight:

  472.51

• Precautions:

  H302, H400

• References & Citations:

  [1]Vang T, et al. LYP inhibits T-cell activation when dissociated from CSK. Nat Chem Biol. 2012 Mar 18;8 (5) :437-446.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  347379-29-7