Denatonium (benzoate)

CAT: 0804-HY-B1146-01Size: 500 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B1146-01Size:500 mg
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Description
Denatonium benzoate (THS-839) is known as the most bitter compound and is commonly used as a deterrent (bittering agent) to activate different types of bitter taste receptors (TAS2Rs) with oral activity. Denatonium benzoate can enhance insulin secretion, has anti-inflammatory effects, and promotes allergy susceptibility[1] [2] [3][4].
CAS Number
[3734-33-6]
Product Name Alternative
THS-839
UNSPSC
12352005
Hazard Statement
H302, H412
Target
Taste Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Endocrinology; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Denatonium-benzoate.html
Concentration
10mM
Purity
99.92
Solubility
DMSO : 20 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic)
Smiles
CC[N+](CC)(CC(NC1=C(C)C=CC=C1C)=O)CC2=CC=CC=C2.O=C([O-])C3=CC=CC=C3
Molecular Formula
C28H34N2O3
Molecular Weight
446.58
Precautions
H302, H412
References & Citations
[1]Plamen I Zagorchev, et al. Denatonium benzoate decreases the effect of histamine in vitro and in rats. Tropical Journal of Pharmaceutical Research September.2020; 19 (9) : 1879-1885. |[2]Huaping Xu, et al. Denatonium Benzoate Exposure Promotes IgE-Mediated Mast Cell Degranulation and Allergy By Upregulating FcεRIα Expression.Hypothesis. posted 29 Sep, 2021 |[3]DALEE. KAUKEINEN, et al. Evaluation of aversive agents to increase the selectivity of rodenticides with emphasis on denatonium benzoate (Bitrex) bittering agent. eScholarship. Proceedings of the Vertebrate Pest Conference, 15 (15) |[4]Weikun Huang, et al. Effects of a bitter substance, denatonium benzoate, on pancreatic hormone secretion. Am J Physiol Endocrinol Metab. 2024 Apr 1;326 (4) :E537-E544.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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