[Glp5,(Me)Phe8,Sar9] Substance P (5-11)

[Glp5,(Me)Phe8,Sar9] Substance P (5-11)

• CAS Number: 77128-69-9
• UNSPSC Description: [Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats[1][2][3].
• Target Antigen: Neurokinin Receptor
• Type: Peptides
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Field of Research: Metabolic Disease; Neurological Disease; Others
• Assay Protocol: https://www.medchemexpress.com/glp5-me-phe8-sar9-substance-p-5-11.html
• Purity: 99.01
• Solubility: DMSO : ≥ 100 mg/mL
• Smiles: CSCC[C@@H](C(N)=O)NC([C@H](CC(C)C)NC(CN(C)C([C@H](CC1=CC=CC=C1)N(C)C([C@@H](NC([C@H](CCC(N)=O)NC([C@@H]2CCC(N2)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O
• Molecular Weight: 880.06
• References & Citations: [1]Elliott PJ, et al. Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area. Brain Res. 1986 Jan 15;363(1):145-7. |[2]Eison AS, et al. Substance P analog, DiMe-C7: evidence for stability in rat brain and prolonged central actions. Science. 1982 Jan 8;215(4529):188-90. |[3]Placenza FM, et al. Infusion of the substance P analogue, DiMe-C7, into the ventral tegmental area induces reinstatement of cocaine-seeking behaviour in rats. Psychopharmacology (Berl). 2004 Dec;177(1-2):111-20.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported