Paroxetine

• Description:

  Paroxetine is an oral inhibitor that falls under the category of selective serotonin reuptake inhibitors (SSRIs) . Paroxetine is also a very weak norepinephrine (NE) reuptake inhibitor, capable of inducing cell apoptosis and having anti-tumor activity. Paroxetine has antidepressant, anti-anxiety, and pain-relieving effects, and it can help improve conditions like obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual anxiety, and chronic headaches[1][2][3][4].

• Product Name Alternative:

  BRL29060

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Adrenergic Receptor; Apoptosis; P2X Receptor; Serotonin Transporter

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cancer; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/paroxetine.html

• Purity:

  99.94

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  FC1=CC=C(C=C1)[C@H]2[C@@H](CNCC2)COC3=CC=C4OCOC4=C3

• Molecular Formula:

  C19H20FNO3

• Molecular Weight:

  329.37

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]M Bourin, et al. Paroxetine: a review. CNS Drug Rev. Spring 2001;7 (1) :25-47|[2]Young-Woo Cho, et al. Paroxetine Induces Apoptosis of Human Breast Cancer MCF-7 Cells through Ca2+-and p38 MAP Kinase-Dependent ROS Generation. Cancers (Basel) . 2019 Jan 9;11 (1) :64.|[3]Malek Zarei, et al. Paroxetine attenuates the development and existing pain in a rat model of neurophatic pain. Iran Biomed J. 2014;18 (2) :94-100.|[4]S Lightowler, et al. Anxiolytic-like effect of paroxetine in a rat social interaction test. Pharmacol Biochem Behav. 1994 Oct;49 (2) :281-5.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Citation 01:

  Biochem Biophys Res Commun. 2024 Jun 13:725:150263.|Cell Rep. 2025 Apr 2;44 (4) :115489.|Front Pharmacol. 2022 Jun 22:13:920643.|Int J Mol Sci. 2025 Mar 31;26 (7) :3236.|NPJ Digit Med. 2025 Nov 17;8 (1) :663.|ACS Omega. 2025 Oct 17;10 (42) :50208-50217.|Autophagy. 2025 May;21 (5) :934-956.|Brain Res. 2019 Oct 1:1720:146296.|Cell. 2021 Apr 15;184 (8) :2167-2182.e22.|Front Pharmacol. 2024 Jul 31:15:1389761.|J Chem Inf Model. 2021 Aug 23;61 (8) :3804-3813.|J Mol Cell Cardiol Plus. 2024 Mar 26:8:100072.|Patent. US20250127769A1.|Sci Rep. 2025 Oct 21;15 (1) :36797.|University of South Carolina. 2025.

• CAS Number:

  [61869-08-7]