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Amisulpride-d5

CAT: 0804-HY-14545S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14545S-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Amisulpride-d5 is the deuterium labeled Amisulpride. Amisulpride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively[1][2].
CAS Number
1216626-17-3
Product Name Alternative
(Rac) -Aramisulpride-d5; (Rac) -Esamisulpride-d5; DAN 2163-d5
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Dopamine Receptor
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Cancer; Neurological Disease
Purity
98.83
Solubility
DMSO : 50mg/mL (ultrasonic) |H2O : 0.2mg/mL (ultrasonic)
Smiles
[2H]C([2H])([2H])C([2H])([2H])N(CCC1)C1CNC(C2=C(C=C(C(S(CC)(=O)=O)=C2)N)OC)=O
Molecular Formula
C17H22D5N3O4S
Molecular Weight
374.51
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Schoemaker H, et al. Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity. J Pharmacol Exp Ther. 1997 Jan;280 (1) :83-97.|[3]Pawar GR, et al. Evaluation of antidepressant like property of amisulpride per se and its comparison with fluoxetine and olanzapine using forced swimming test in albino mice. Acta Pol Pharm. 2009 May-Jun;66 (3) :327-31.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
D3 Receptor

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