Amisulpride

• Description :

  Amisulpride ((Rac) -Aramisulpride) is a racemic (50:50) mixture of the R-Amisulpride (HY-109167) and S-Amisulpride (HY-126068) . Amisulpride is a dopamine D2/D3 receptor antagonist with Ki values of 2.8 and 3.2 nM for human dopamine b>D2 and b>D3, respectively. Amisulpride is a 5-HT7 receptor antagonist with a Ki of 44 nM. Amisulpride can be used in psychiatric research[1][2][3].

• Product Name Alternative :

  (Rac) -Aramisulpride; (Rac) -Esamisulpride; DAN 2163

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  5-HT Receptor; Dopamine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Amisulpride.html

• Purity :

  99.81

• Solubility :

  DMSO : 50 mg/mL (ultrasonic) |H2O : 0.2 mg/mL (ultrasonic)

• Smiles :

  CCN1C(CNC(C2=CC(S(=O)(CC)=O)=C(N)C=C2OC)=O)CCC1

• Molecular Formula :

  C17H27N3O4S

• Molecular Weight :

  369.48

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Schoemaker H, et al. Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity. J Pharmacol Exp Ther. 1997 Jan;280 (1) :83-97.|[2]Pawar GR, et al. Evaluation of antidepressant like property of amisulpride per se and its comparison with fluoxetine and olanzapine using forced swimming test in albino mice. Acta Pol Pharm. 2009 May-Jun;66 (3) :327-31.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  5-HT7 Receptor; D2 Receptor; D3 Receptor

• CAS Number :

  [71675-85-9]