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(R) -Colchicine

CAT: 0013-GTR19280993-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19280993-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(R) -Colchicine is the R-isomer of Colchicine. Colchicine is an orally active alkaloid that serves as an effective microtubule protein inhibitor and disruptor. It inhibits microtubule polymerization with an IC50 of 3 nM and acts as a competitive antagonist of the α3 glycine receptor (GlyR) . Additionally, Colchicine prevents NSAID-induced small intestinal injury by inhibiting the activation of the NLRP3 inflammasome. It exhibits extensive anti-inflammatory, immunosuppressive, and potent antifibrotic effects, with potential applications in gouty arthritis research.
CAS Number
75520-89-7
Smiles
O (C) C1=C2C=3C ([C@H] (NC (C) =O) CCC2=CC (OC) =C1OC) =CC (=O) C (OC) =CC3
Molecular Formula
C22H25NO6
Molecular Weight
399.44
Notes
For research use only.

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