TRI-611

CAT: 0013-GTR19277325-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19277325-01Size:1 mg

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Description

TRI-611 is an oral, blood-brain barrier-penetrating ALK molecular chaperone degrader. TRI-611 specifically binds to E3 ligases, recruits and marks oncogenic ALK fusion proteins, and mediates their selective degradation via the ubiquitin-proteasome system. TRI-611 induces tumor regression in xenograft models of ALK-positive NSCLC. TRI-611 is equally effective in TKI-resistant tumor models. TRI-611 is suitable for use in studies of ALK-positive non-small cell lung cancer and TKI-resistant tumors.

CAS Number

3117940-39-0

Smiles

O=C1OC2=CC=C (C=C2N1C3C (=O) NC (=O) CC3) CC4=NC (=NO4) C=5C=CC=CC5

Molecular Formula

C21H16N4O5

Molecular Weight

404.38

Storage Conditions

-20°C

Notes

For research use only.

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Alternative Products

Catalog	Name
C21572-25mg	TRI-611
T2020-01	RGW 611
HY-107840-01	RGW-611
MBS5799626	AL-611
T69349-01	HPR-611
MBS5783236	NK 611
HY-106122	NK-611
HY-171185	CP-611,781
A22135-10	RGW 611 10mg
A22135-200	RGW 611 200mg

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