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Phe-PEG1-Dasa

CAT: 0013-GTR19277087-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19277087-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Phe-PEG1-Dasa is a BCR-ABL PROTAC degrader with a DC50 of 1.56 nM. It employs a single amino acid (Phe) as an E3 ligase ligand, leveraging the N-end rule pathway to induce target protein degradation, thereby significantly reducing its molecular size, earning the name mini-PROTAC. Phe-PEG1-Dasa markedly inhibits the proliferation of K562 cells and is applicable in leukemia research.
CAS Number
3037776-73-8
Smiles
N (C1=CC (N2CCN (CCOC (CCOCCNC ([C@H] (CC3=CC=CC=C3) N) =O) =O) CC2) =NC (C) =N1) C=4SC (C (NC5=C (C) C=CC=C5Cl) =O) =CN4
Molecular Formula
C36H44ClN9O5S
Molecular Weight
750.32
Storage Conditions
-20°C
Notes
For research use only.

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