Arg-PEG1-Tαsyn

CAT: 0013-GTR19277072-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19277072-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Arg-PEG1-Tαsyn is a PROTAC degrader targeting α-synuclein (α-syn), with a DC50 of 0.28 μM in U251 cells. This compound utilizes arginine (Arg) as the E3 ligase ligand and a benzothiazole-aniline variant as the warhead for α-syn targeting. It effectively degrades both wild-type α-syn and its A53T mutant in mammalian cells. In vitro, Arg-PEG1-Tαsyn significantly reduces α-syn aggregation via the E3 ubiquitin ligase UBR1. In vivo, it demonstrates good safety and significantly improves dopaminergic neuron damage and motor dysfunction. Arg-PEG1-Tαsyn is useful in Parkinson's disease research.

Storage Conditions

-20°C

Notes

For research use only.

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