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SK4454

CAT: 0013-GTR19276205-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19276205-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SK4454 is a selective AURKAPROTAC degrader that targets the AURKA protein with an IC50 of 8 nM. It binds to NanoLuc-AURKA with an IC50 of 20 nM. SK4454 effectively reduces MYCN levels in MYCN-amplified neuroblastoma cells, although its activity is limited by MDR1-mediated efflux. In vivo, SK4454 efficiently decreases AURKA levels. It is useful for research related to neuroblastoma.
Storage Conditions
-20°C
Notes
For research use only.

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