JNK-IN-17

CAT: 0013-GTR19275028-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19275028-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

JNK-IN-17 (Compound 9J) is a selective and potent inhibitor of JNK, exhibiting IC50 values of 0.039 μM for JNK1 and 0.079 μM for JNK3. It effectively inhibits c-Jun phosphorylation in Streptozotocin-induced INS-1 pancreatic β cells, with an IC50 of 0.082 μM. JNK-IN-17 shows inhibition rates of ≤ 33% for the four major P450 isoforms (2C9, 2D6, 3A4, 1A2) in human liver microsomes, indicating a relatively low risk of drug interactions. This compound can be utilized in research on neurological and metabolic disorders, including Parkinson's disease.

CAS Number

1128096-58-1

Smiles

N#CC1=CC (=CC (=C1) N2CCOCC2) C3=NC (=NC=C3) NC4=CC=C (C=C4) N5N=C (N=C5) C=6C=NC=CC6

Molecular Formula

C28H23N9O

Molecular Weight

501.55

Storage Conditions

-20°C

Notes

For research use only.

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