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(R, R) -Birelentinib

CAT: 0013-GTR19275009-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19275009-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(R, R) -Birelentinib (Compound 14) is a potent BTK inhibitor with IC50 values of 0.7 nM for BTKWT and 0.86 nM for BTKC481S. It effectively inhibits BTK autophosphorylation with an IC50 of 24.3 nM. This compound exhibits significant antiproliferative activity against both wild-type and C481S mutant HEK293 cells, and is useful for studying resistant B-cell malignancies.
CAS Number
2662512-14-1
Smiles
NC=1C2=C (N=C (N2N=CN1) [C@H]3CC[C@H] (CO) OC3) C4=CC=C (OC5=C (F) C (F) =CC=C5) C=C4
Molecular Formula
C23H21F2N5O3
Molecular Weight
453.45
Storage Conditions
-20°C
Notes
For research use only.

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