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W-5 (hydrochloride)

CAT: 0804-HY-100911-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100911-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
W-5 hydrochloride is a calmodulin antagonist. W-5 hydrochloride inhibits phosphodiesterase activation with an IC50 value of 240 µM. W-5 hydrochloride can be used as a negative control for W-7[2].
CAS Number
61714-25-8
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Calmodulin
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/w-5-hydrochloride.html
Purity
99.93
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=S(C1=C2C=CC=CC2=CC=C1)(NCCCCCCN)=O.[H]Cl
Molecular Formula
C16H23ClN2O2S
Molecular Weight
342.88
Precautions
H315, H319, H335
References & Citations
[1]Suzuki S, et al. Enhancement of the cAMP-induced apolipoprotein-mediated cellular lipid release by calmodulin inhibitors W7 and W5 from RAW 264 mouse macrophage cell line cells. J Cardiovasc Pharmacol. 2000 Nov;36 (5) :609-16.|[2]Yokokura S, et al. Calmodulin antagonists induce cell cycle arrest and apoptosis in vitro and inhibit tumor growth in vivo in human multiple myeloma. BMC Cancer. 2014 Nov 26;14:882.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

N-(6-aminohexyl)-1-naphthalenesulfonamide hydrochloride
CAS Number61714-25-8
PubChem CID173829
IUPAC NameN-(6-aminohexyl)naphthalene-1-sulfonamide;hydrochloride
Molecular FormulaC16H23ClN2O2S
Molecular Weight342.9
Topological Polar Surface Area80.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count8
Heavy Atom Count22
Formal Charge0
Complexity392
SMILES
C1=CC=C2C(=C1)C=CC=C2S(=O)(=O)NCCCCCCN.Cl
InChI
InChI=1S/C16H22N2O2S.ClH/c17-12-5-1-2-6-13-18-21(19,20)16-11-7-9-14-8-3-4-10-15(14)16;/h3-4,7-11,18H,1-2,5-6,12-13,17H2;1H
InChIKey
HOCSVIGHWPLMFC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(6-aminohexyl)-1-naphthalenesulfonamide hydrochloride
CAS: 61714-25-8
CID: 173829
Formula: C16H23ClN2O2S
MW: 342.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight342.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count8
Exact Mass342.1168768
Monoisotopic Mass342.1168768
Topological Polar Surface Area80.6 Ų
Heavy Atom Count22
Formal Charge0
Complexity392
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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