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Factor B-IN-8

CAT: 0013-GTR19274922-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274922-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Factor B-IN-8 (Compound (3R,4R) -15) is a potent, selective, and orally active inhibitor of Factor B, demonstrating an IC50 value of 10.2 nM. It effectively blocks the interaction between Factor B and C3b, thus preventing the formation of the C3 convertase (C3bBb) . Additionally, Factor B-IN-8 hinders the deposition of the membrane attack complex (MAC) along the alternative pathway with an IC50 of 59.3 nM. This compound reduces the cleavage of Factor B protein and lessens the deposition of complement C3d in the glomeruli and renal tubules. Factor B-IN-8 is applicable in the research of arthritis and paroxysmal nocturnal hemoglobinuria (PNH) .
CAS Number
3049710-19-9
Smiles
O (C1=C2C (=C (C) C=C1OC) NC=C2) [C@H]3[C@@H] (CN (CC (F) (F) F) CC3) C4=CC=C (C (O) =O) C=C4
Molecular Formula
C24H25F3N2O4
Molecular Weight
462.47
Storage Conditions
-20°C
Notes
For research use only.

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