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O-Desmethyl dacomitinib

CAT: 0013-GTR19274890-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274890-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
O-Desmethyl dacomitinib (PF-05199265) is the primary circulating metabolite of Dacomitinib and acts as a pan-ErbB tyrosine kinase inhibitor, targeting epidermal growth factor receptors. The exposure level of O-Desmethyl dacomitinib is significantly lower than that of Dacomitinib, and its formation is highly dependent on CYP2D6 enzyme activity.
CAS Number
2468202-15-3
Smiles
N (C=1C2=C (C=C (O) C (NC (/C=C/CN3CCCCC3) =O) =C2) N=CN1) C4=CC (Cl) =C (F) C=C4
Molecular Formula
C23H23ClFN5O2
Molecular Weight
455.92
Storage Conditions
-20°C
Notes
For research use only.

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