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CAII-IN-11

CAT: 0013-GTR19274861-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274861-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CAII-IN-11 (Compound A1) is a dual-targeted compound that includes an hCA II inhibitor segment (IC50= 2 nM) and a NO donor component. It also shows inhibitory activity against hCA IX, hCA XII, and hCA I, with IC50 values of 6, 3, and 152 nM, respectively. CAII-IN-11 significantly elevates cGMP levels in human trabecular meshwork cells. Furthermore, it reduces apoptosis of retinal ganglion cells by decreasing oxidative stress (ROS levels), inhibiting astrocytes, and NLRP3 inflammasome activation. In a rabbit model, CAII-IN-11 demonstrates intraocular pressure-lowering activity, making it a potential candidate for glaucoma research.
Storage Conditions
-20°C
Notes
For research use only.

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