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CAII-IN-12

CAT: 0013-GTR19273843-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273843-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CAII-IN-12 (compound 6c) is a potent and selective inhibitor of carbonic anhydrase (CA) II and VII, with inhibition constants hCA II Ki= 47.8 nM and hCA VII Ki= 3.6 nM, and exhibits antiepileptic activity. It is selective for hCA I with a Ki of 370 nM. In mouse models of epilepsy induced by Pentylenetetrazol and Pilocarpine, CAII-IN-12 demonstrates strong anticonvulsant effects. Additionally, it increases the expression of KCC2 in the hippocampus, maintains neuronal integrity, and reduces mTOR activity. CAII-IN-12 is applicable for epilepsy research.
Storage Conditions
-20°C
Notes
For research use only.

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