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Cx43 HC-IN-1

CAT: 0013-GTR19274823-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274823-01Size:10 mg
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Description
Cx43 HC-IN-1 (Compound D4) is a selective, orally active inhibitor of connexin hemichannels (Cx43 HC) . It effectively suppresses hemichannel activity mediated by Cx43/Cx45 in denervated skeletal muscle fibers, significantly enhancing neuronal reinnervation of muscle fibers. By inhibiting hemichannels in brain glial cells, Cx43 HC-IN-1 reduces neuroinflammation and neuronal hyperexcitability, alleviating seizures in mice. It is applicable for research on epilepsy and muscular disorders.
CAS Number
1840896-10-7
Smiles
[C@@H] (C (=O) C1=CC=C (Cl) C=C1) (OC (=O) C2=NC3=C (C=C2) C=CC=C3) C4=CC=CC=C4
Molecular Formula
C24H16ClNO3
Molecular Weight
401.85
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(r)-2-(4-Chlorophenyl)-2-oxo-1-phenylethyl quinoline-2-carboxylate
CAS Number1840896-10-7
PubChem CID92152146
IUPAC Name[(1R)-2-(4-chlorophenyl)-2-oxo-1-phenylethyl] quinoline-2-carboxylate
Molecular FormulaC24H16ClNO3
Molecular Weight401.8
XLogP6.1
Topological Polar Surface Area56.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Heavy Atom Count29
Formal Charge0
Complexity568
SMILES
C1=CC=C(C=C1)[C@H](C(=O)C2=CC=C(C=C2)Cl)OC(=O)C3=NC4=CC=CC=C4C=C3
InChI
InChI=1S/C24H16ClNO3/c25-19-13-10-17(11-14-19)22(27)23(18-7-2-1-3-8-18)29-24(28)21-15-12-16-6-4-5-9-20(16)26-21/h1-15,23H/t23-/m1/s1
InChIKey
WOKCOSHBOZBKRP-HSZRJFAPSA-N
Chemical Structure
2D Structure
2D structure of (r)-2-(4-Chlorophenyl)-2-oxo-1-phenylethyl quinoline-2-carboxylate
CAS: 1840896-10-7
CID: 92152146
Formula: C24H16ClNO3
MW: 401.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight401.8
XLogP36.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass401.0818711
Monoisotopic Mass401.0818711
Topological Polar Surface Area56.3 Ų
Heavy Atom Count29
Formal Charge0
Complexity568
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

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Cx43A11-SRabbit Anti-Mouse Connexin 43 (Cx43) Antiserum #1
Cx43A11-PMouse Connexin 43 (Cx43) Control/blocking peptide # 1
abx615885Gap Junction Alpha-1 Protein / CX43 (GJA1) Peptide
C7857-07CConnexin 43 (Cx43, Gap Junction Alpha 1 Protein, CxA-1)
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