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KRAS G13D-IN-2

CAT: 0013-GTR19274590-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274590-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KRAS G13D-IN-2 (compound 8b) is a potent orally active inhibitor of KRAS G13D, with IC50 values of 1.95 μM in HCT-116G13D and 2.16 μM in HCT-15G13D. It induces G1 phase arrest and mitochondrial membrane depolarization. By inhibiting CDK6/TWIST1, KRAS G13D-IN-2 triggers cellular senescence. Additionally, it suppresses tumor growth in mouse models and is useful for studying KRAS G13D mutant colorectal cancer.
Storage Conditions
-20°C
Notes
For research use only.

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