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XRF-1021

CAT: 0013-GTR19274456-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274456-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
XRF-1021 is an orally active HIPK2 inhibitor with an IC50 value of 0.18 μM. It reduces the expression of fibrosis markers such as fibronectin, type I collagen, and α-SMA in NRK-49F and HK-2 cells stimulated by TGF-β1. XRF-1021 blocks signaling pathways including TGF-β, NF-κB, p53, Wnt/β-catenin, and Notch. Additionally, it alleviates renal injury and fibrosis in vivo and can be utilized for research in chronic kidney disease.
CAS Number
2968523-32-0
Smiles
FC1=CN=C (N=C1NC2=CC=C (C=C2) N3CCNCC3) N4C (=NC=5C=CC=CC54) N
Molecular Formula
C21H21FN8
Molecular Weight
404.45
Storage Conditions
-20°C
Notes
For research use only.

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