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PMV6-PEG4-BI2536

CAT: 0013-GTR19274239-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274239-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PMV6-PEG4-BI2536 is a dual-functional compound targeting both p53-Y220C and PLK1. It consists of a high-affinity binder for the p53-Y220C mutant (Kd≈ 2.5 nM) and a potent PLK1 kinase inhibitor (IC50= 0.83 nM) . This compound induces G2/M arrest and apoptosis in TP53Y220C cells through PLK1 mislocalization and kinase inhibition, independent of p53 transcriptional reactivation. PMV6-PEG4-BI2536 is applicable for researching TP53 mutant cancers.
Storage Conditions
-20°C
Notes
For research use only.

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