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HPK1-IN-65

CAT: 0013-GTR19274195-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274195-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HPK1-IN-65 is a selective, orally active HPK1 inhibitor with an IC50 value of less than 5 nM, demonstrating 1257-fold selectivity over the MAP4K kinase family member GLK. It inhibits pSLP76 phosphorylation with an IC50 of 92.3 nM and stimulates IL-2 production with an EC50 of 398 nM. Additionally, HPK1-IN-65 suppresses the phosphorylation of the TCR-induced SLP76Ser376 site in a dose-dependent manner. This compound is also applicable in colon cancer research.
Storage Conditions
-20°C
Notes
For research use only.

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