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Eseroline

CAT: 0013-GTR19274148-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274148-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Eseroline is a potent μ-opioid receptor agonist and a hydrolytic metabolite of Physostigmine. It serves as a selective and competitive acetylcholinesterase (AChE) inhibitor, with inhibition constants (Ki) of 0.1 μM for AChE and 200 μM for butyrylcholinesterase (BuChE) . Eseroline acts as an allosteric potentiating ligand of nicotinic acetylcholine receptors (nAChR-APL), enhancing Ach-induced nAChR signaling without directly activating the receptor. The compound is neurotoxic, causing cellular membrane damage (LDH leakage) and energy metabolism collapse (ATP depletion) . Additionally, Eseroline can be utilized in Alzheimer's disease research.
CAS Number
469-22-7
Smiles
C[C@]12C=3C (N (C) [C@]1 (N (C) CC2) [H]) =CC=C (O) C3
Molecular Formula
C13H18N2O
Molecular Weight
218.3
Storage Conditions
-20°C
Notes
For research use only.

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