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LOXL2/sGC modulator-2

CAT: 0013-GTR19274126-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274126-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LOXL2/sGC modulator-2 (Compound 9k) is a selective, orally active dual-target modulator of lysyl oxidase-like protein 2 (LOXL2) and soluble guanylate cyclase (sGC) . It inhibits LOXL2 with an IC50 of 0.1 μM and acts as an sGC activator. This compound can improve vascular remodeling and reduce pulmonary arterial pressure while downregulating PKG1, PCNA, α-SMA, collagen I, and fibronectin levels. LOXL2/sGC modulator-2 is useful for studying pulmonary arterial hypertension.
Storage Conditions
-20°C
Notes
For research use only.

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