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LOXL2/sGC modulator-1

CAT: 0013-GTR19273745-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273745-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LOXL2/sGC modulator-1 (Compound 11k) is an LOXL2 inhibitor with an IC50 of 0.13 μM and acts as an sGC activator. It shows good selectivity for LOX (IC50 > 45.9 μM) and LOXL3 (IC50 = 1.30 μM) . In the presence of the gGC inhibitor ODQ, it significantly increases intracellular cGMP levels. LOXL2/sGC modulator-1 effectively inhibits hypoxia-induced collagen deposition and cross-linking while promoting vasodilation. This compound is useful for researching pulmonary arterial hypertension.
Storage Conditions
-20°C
Notes
For research use only.

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