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BXI-72

CAT: 0013-GTR19162990-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162990-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BXI-72 (NSC334072, Hoechst 33342) is a potent, selective small molecule Bcl-XL inhibitor that targets the BH3 domain of Bcl-XL (Kd=0.9 nM) ; displays very low binding affinities with Bcl2 (Ki=283 nM), Mcl-1, Bcl-w and Bfl-1/A1 (Ki>1500 nM) ; potently suppresses lung cancer cell growth (H1299=0.49 uM, A549 IC50=0.68 uM), displays relatively selective cytotoxicity against lung cancer cells compared to normal human bronchial epithelial cells; caunses disruption of Bcl-XL/Bak or Bcl-XL/Bax interaction, oligomerization of Bak, and cytochrome c release from mitochondria in cells, BXI-72 exhibits more potent efficacy against human lung cancer than ABT-737 but less degree in platelet reduction in vivo.
CAS Number
23491-52-3
Product Name Alternative
NSC334072 | Bcl-XL inhibitor BXI-72 | Hoechst 33342
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 6.25 mg/mL (13.81 mM)
Smiles
CN1CCN (C2=CC=C3C (N=C (C4=CC=C5C (N=C (C6=CC=C (OCC) C=C6) N5) =C4) N3) =C2) CC1.[H]Cl.[H]Cl.[H]Cl
Molecular Formula
C27H29ClN6O
Molecular Weight
489.01
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2'- (4-ethoxyphenyl) -5- (4-methylpiperazin-1-yl) -1H,1'H-2,5'-bibenzo[d]imidazole

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Alternative Products

CatalogName
M13672-01BXI-72
ABC-TC0036A-72
138595-AFTAG-72 (Tumor-associated Glycoprotein 72, TAG 72)
172153-01TAG-72 (CA 72.4, Tumor Associated GlycoProtein 72)
MBS6122470-01TAG-72 (Tumor-associated Glycoprotein 72, TAG 72) (PE)
138595-AF-BiotinTAG-72 (Tumor-associated Glycoprotein 72, TAG 72) (Biotin)
MBS6122465-01TAG-72 (Tumor-associated Glycoprotein 72, TAG 72) (AP)
138595-AF-HRPTAG-72 (Tumor-associated Glycoprotein 72, TAG 72) (HRP)
138595-AF-APCTAG-72 (Tumor-associated Glycoprotein 72, TAG 72) (APC)
138595-AF-FITCTAG-72 (Tumor-associated Glycoprotein 72, TAG 72) (FITC)

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