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Ca2+ -Langerin-IN-1

CAT: 0013-GTR19273892-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273892-01Size:10 mg
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Description
Ca2+ -Langerin-IN-1 (Compound 3) is an allosteric inhibitor of the protein Langerin, a C-type lectin expressed on Langerhans cells, which plays a crucial role in pathogen recognition and innate immune activation. Under Ca2+ and Ca2+-free competitive conditions, the KD values of Ca2+ -Langerin-IN-1 for the murine Langerin CRD domain are 17 μM and 53 μM, respectively. It induces conformational changes and competitively displaces Ca2+, thereby inhibiting the carbohydrate recognition function of the protein. Ca2+ -Langerin-IN-1 can be utilized in studies of immunoregulatory therapies.
CAS Number
79932-56-2
Smiles
O=C (O) C1=CN=C2SC (=C (N2C1=O) C) C
Molecular Formula
C9H8N2O3S
Molecular Weight
224.23
Storage Conditions
-20°C
Notes
For research use only.

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