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Langerin Antibody / CD207

CAT: 0013-GTR18574901Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18574901Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2+-dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG) . BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein.
UniProt
Q9UJ71
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 74-213) was used as the immunogen for the Langerin antibody.
Clonality
Monoclonal
Clone
LGRN/1821
Conjugation
Unconjugated
Field of Research
Immunology & Inflammation
Purification
Protein G affinity chromatography
Dilution
ELISA (order BSA-free format for coating), Western blot: 1-2ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the Langerin antibody should be determined by the researcher.
Tested Applications
ELISA, WB
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG2a, kappa

UniProtKB · Q9UJ71

C-type lectin domain family 4 member K

CLC4K_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9UJ71
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CD207
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
—
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Domain

Coiled coilSignal-anchorTransmembraneTransmembrane helix

PTM

Disulfide bondGlycoprotein

Ligand

Lectin

Cellular component

Membrane

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