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STAT3-IN-52

CAT: 0013-GTR19273753-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273753-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
STAT3-IN-52 (Compound 9) is a selective and orally active inhibitor of signal transducer and activator of transcription 3 (STAT3) . It binds to the pY705 site of STAT3 with a Ki of 440 nM, effectively hindering STAT3 phosphorylation and dimerization. STAT3-IN-52 exhibits potent cytotoxicity against various cancer cells, such as breast cancer MDA-MB-231 (IC50 of 0.7 μM), medulloblastoma UW426, and pancreatic cancer BKPC3 cells. The compound induces apoptosis, inhibits STAT3's nuclear translocation and DNA-binding activity, and downregulates the expression of the STAT3 target gene MMP9. STAT3-IN-52 is useful in research related to cancers with aberrant STAT3 activation.
CAS Number
1556861-34-7
Smiles
O=C1C=C (NC=2C=CC=CC2N3CCNCC3) C (=O) C4=CC=CC (=C14) S (=O) (=O) N
Molecular Formula
C20H20N4O4S
Molecular Weight
412.46
Storage Conditions
-20°C
Notes
For research use only.

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HY-177990-01STAT3-IN-52
583293STAT3

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