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STING-IN-17

CAT: 0013-GTR19273565-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273565-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
STING-IN-17 is an orally active inhibitor of STING (human STING IC50= 29 nM, murine STING IC50= 15 nM) . It effectively suppresses the phosphorylation of STING, TBK1, and IRF3. The compound inhibits the expression of IP10, IFNB1, and ISG56 mRNA in a dose-dependent manner. Additionally, STING-IN-17 reduces ROS and inhibits the expression of cleaved-PARP/caspase-3. It shows potential for improving renal function and can be utilized in research on inflammatory diseases such as acute kidney injury.
CAS Number
3069635-58-8
Smiles
O=C (NC1=CNC=2C=CC=CC21) C3=CC=C4C (=C3) N (C (=O) C4 (C) C) CC5CN (C6=CC (F) =CC (=C6) C (F) (F) F) C5
Molecular Formula
C30H26F4N4O2
Molecular Weight
550.56
Storage Conditions
-20°C
Notes
For research use only.

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