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RPR107393

CAT: 0013-GTR19274435-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274435-02Size:10 mg
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Description
RPR107393 is an orally active and selective inhibitor of squalene synthase (SQS) . It inhibits squalene synthase in rat liver microsomes with an IC50 of 0.8 nM. By increasing cellular farnesol and its derivatives, RPR107393 suppresses fatty acid biosynthesis, thereby reducing triglyceride synthesis. It also lowers plasma cholesterol in rats and marmosets. RPR107393 is applicable in research related to metabolic diseases, such as hypercholesterolemia, hypertriglyceridemia, and atherosclerosis.
CAS Number
190841-57-7
Smiles
OC1 (CN2CCC1CC2) C3=CC=C (C4=CC=C5N=CC=CC5=C4) C=C3.Cl.Cl
Molecular Formula
C22H24Cl2N2O
Molecular Weight
403.35
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

3-(4-Quinolin-6-ylphenyl)-1-azabicyclo[2.2.2]octan-3-ol;dihydrochloride
CAS Number190841-57-7
PubChem CID9887414
IUPAC Name3-(4-quinolin-6-ylphenyl)-1-azabicyclo[2.2.2]octan-3-ol;dihydrochloride
Molecular FormulaC22H24Cl2N2O
Molecular Weight403.3
Topological Polar Surface Area36.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count27
Formal Charge0
Complexity467
SMILES
C1CN2CCC1C(C2)(C3=CC=C(C=C3)C4=CC5=C(C=C4)N=CC=C5)O.Cl.Cl
InChI
InChI=1S/C22H22N2O.2ClH/c25-22(15-24-12-9-20(22)10-13-24)19-6-3-16(4-7-19)17-5-8-21-18(14-17)2-1-11-23-21;;/h1-8,11,14,20,25H,9-10,12-13,15H2;2*1H
InChIKey
ALEHEGZTOBQIGC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-(4-Quinolin-6-ylphenyl)-1-azabicyclo[2.2.2]octan-3-ol;dihydrochloride
CAS: 190841-57-7
CID: 9887414
Formula: C22H24Cl2N2O
MW: 403.3
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight403.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass402.1265688
Monoisotopic Mass402.1265688
Topological Polar Surface Area36.4 Ų
Heavy Atom Count27
Formal Charge0
Complexity467
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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CatalogName
HY-100299ARPR107393
BUP14133-01RPR107393 free base
A13051-50RPR107393 free base 50mg
A13051-10RPR107393 free base 10mg
A13051-1RPR107393 free base 1mg
A13051-25RPR107393 free base 25mg
A13051-5RPR107393 free base 5mg

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