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KOR agonist 6

CAT: 0013-GTR19264708-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19264708-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KOR agonist 6 is a KOR agonist with a Ki value of 0.25 pM. In CHO cells, it exhibits agonistic activity on MOR and DOR and inhibits forskolin-stimulated cAMP accumulation. The compound stimulates KOR-mediated [35S]GTPγS binding in HEK293 cells expressing KOR and effectively suppresses cAMP accumulation as a potent agonist, showing lower β-arrestin recruitment efficacy. Additionally, KOR agonist 6 demonstrates analgesic effects in mice and can be employed in the study of analgesics with reduced central nervous system (CNS) side effects.
Field of Research
Metabolism Research, Neuroscience, Pharmacology & Drug Discovery
Storage Conditions
-20°C
Notes
For research use only.

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