Products for Research Use Only
RegisterLogin

A-259745

CAT: 0013-GTR19273680-02Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19273680-02Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
A-259745 is an orally active antimitotic agent that binds to the colchicine site on tubulin. It exhibits potent in vitro cytotoxic activity against both multidrug-resistant and non-multidrug-resistant cancer cell lines, with ED50 values of 0.018 μM for HCT-15 and 0.028 μM for NCI-H460 cells. A-259745 inhibits tubulin polymerization, disrupting the dynamic equilibrium of the mitotic spindle, causing dividing cells to arrest in the metaphase-anaphase transition, which subsequently induces apoptosis (apoptosis) . In mouse tumor models, A-259745 demonstrates dose-dependent antitumor efficacy and is useful for cancer research.
CAS Number
256934-83-5
Smiles
N1=C (OC (C2=CC (OC) =C (OC) C (OC) =C2) C1) C=3C=CC4=C (C=CN4C) C3
Molecular Formula
C21H22N2O4
Molecular Weight
366.42
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

A-289099

structure in first source

CAS Number256934-83-5
PubChem CID9820528
IUPAC Name2-(1-methylindol-5-yl)-5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1,3-oxazole
Molecular FormulaC21H22N2O4
Molecular Weight366.4
XLogP3
Topological Polar Surface Area54.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count27
Formal Charge0
Complexity528
SMILES
CN1C=CC2=C1C=CC(=C2)C3=NCC(O3)C4=CC(=C(C(=C4)OC)OC)OC
InChI
InChI=1S/C21H22N2O4/c1-23-8-7-13-9-14(5-6-16(13)23)21-22-12-19(27-21)15-10-17(24-2)20(26-4)18(11-15)25-3/h5-11,19H,12H2,1-4H3
InChIKey
VVXYHELHUZGLHK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of A-289099
CAS: 256934-83-5
CID: 9820528
Formula: C21H22N2O4
MW: 366.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight366.4
XLogP33
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass366.15795719
Monoisotopic Mass366.15795719
Topological Polar Surface Area54.2 Ų
Heavy Atom Count27
Formal Charge0
Complexity528
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19196854-01Org-25935

Alternative Products

CatalogName
HY-101741A-259745

Popular Products