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A-259745

CAT: 0013-GTR19273680-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273680-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A-259745 is an orally active antimitotic agent that binds to the colchicine site on tubulin. It exhibits potent in vitro cytotoxic activity against both multidrug-resistant and non-multidrug-resistant cancer cell lines, with ED50 values of 0.018 μM for HCT-15 and 0.028 μM for NCI-H460 cells. A-259745 inhibits tubulin polymerization, disrupting the dynamic equilibrium of the mitotic spindle, causing dividing cells to arrest in the metaphase-anaphase transition, which subsequently induces apoptosis (apoptosis) . In mouse tumor models, A-259745 demonstrates dose-dependent antitumor efficacy and is useful for cancer research.
CAS Number
256934-83-5
Smiles
N1=C (OC (C2=CC (OC) =C (OC) C (OC) =C2) C1) C=3C=CC4=C (C=CN4C) C3
Molecular Formula
C21H22N2O4
Molecular Weight
366.42
Storage Conditions
-20°C
Notes
For research use only.

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