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RET-IN-31

CAT: 0013-GTR19273558-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273558-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RET-IN-31 (Compound 13) is an orally active, selective RET inhibitor with IC50 values of 1.4 nM, 1.9 nM, and 3.8 nM for RETWT, RETV804L, and RETV804M, respectively. It also inhibits hERG and Cytochrome P450, with IC50 values of 13.6 μM, 7.9 μM, 12.8 μM, 16.9 μM, 8.9 μM, and 13.0 μM for CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4-M, and CYP3A4-T, respectively. RET-IN-31 exhibits anticancer properties against cancers driven by activated RET mutations and gene fusions.
CAS Number
2491726-04-4
Smiles
O=C (C1=CN=C (C=C1) N2N=CC (F) =C2) N3C4CN (C=5N=C (C=C (N5) C) NC6=NNC (=C6) C) CC3CC4
Molecular Formula
C24H25FN10O
Molecular Weight
488.53
Storage Conditions
-20°C
Notes
For research use only.

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