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RET Antibody / c-RET

CAT: 0013-GTR18571724Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18571724Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The Ret proto-oncogene is structurally related to the growing family of tyrosine kinase transmembrane receptors and is involved in GDNF signaling. RET expression is reported in several regions of the central nervous system; in the developing cranial nerve ganglia and a subset of cells within dorsal root ganglia, in motor neurons in the spinal cord and hindbrain, in neuro-retina and the growing tips of the renal collecting ducts in developing kidney. Alterations in the RET gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma, and a congenital developmental disorder known as Hirschsprung s disease.
UniProt
P07949
Reactivity
Human
Immunogen
A recombinant fragment (within amino acids 702-848) of human RET protein was used as the immunogen for the RET antibody.
Clonality
Monoclonal
Clone
RET/8786
Conjugation
Unconjugated
Field of Research
Signal Transduction
Purification
Protein A/G affinity
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the RET antibody should be determined by the researcher.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG2c, kappa

UniProtKB · P07949

Proto-oncogene tyrosine-protein kinase receptor Ret

RET_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P07949
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
RET
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
A8K6Z2, Q15250, Q9BTB0, Q9H4A2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Ligand

ATP-bindingNucleotide-binding

Biological process

Cell adhesion

Cellular component

Cell membraneEndosomeMembrane

Disease

Disease variantHirschsprung diseaseProto-oncogene

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

KinaseReceptorTransferaseTyrosine-protein kinase

Domain

SignalTransmembraneTransmembrane helix

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