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HDAC6-IN-67

CAT: 0013-GTR19273530-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273530-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC6-IN-67 is a selective HDAC6 inhibitor with an IC50 of 17.15 nM, demonstrating 19-fold selectivity over HDAC1. It selectively inhibits HDAC6 by interacting with Ser531 and His614. HDAC6-IN-67 induces apoptosis by cleaving caspase9, 8, 3 and PARP, upregulating Bax expression, and downregulating Bcl-2 expression. It effectively acetylates α-tubulin in MCF-7/ADR cells without affecting histone H3 acetylation. HDAC6-IN-67 is applicable in breast cancer research.
CAS Number
2196247-20-6
Smiles
O=C (NO) C1=CC=C (C=C1) CN2C (=O) C=3C=CC=CC3N=C2C
Molecular Formula
C17H15N3O3
Molecular Weight
309.33
Storage Conditions
-20°C
Notes
For research use only.

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