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Trpvicin

CAT: 0013-GTR19273250-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273250-02Size:10 mg
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Description
Trpvicin is a potent and subtype-selective TRPV3 inhibitor, exhibiting IC50 values of 0.41 μM for hTRPV3-WT and 0.22 μM for hTRPV3-G573S mutants. It shows only weak inhibitory effects on other TRP family members (such as TRPV1/2/4/5/6, TRPA1, and TRPM8) . By binding to the VSLD-PD site, Trpvicin stabilizes the closed state of TRPV3 channels, and in the G573S mutant, it enters the central cavity, enhancing inhibition through symmetry restructuring and pore blockage. In mouse models, Trpvicin can inhibit itching and hair loss and is applicable for research related to inflammation and immunology.
CAS Number
2019994-90-0
Smiles
N#CC (C1=NC=CC (=C1) C=2SC (=NC2C (F) (F) F) NC (=O) C=3C (=NC=NC3OC) OC) (C) C
Molecular Formula
C20H17F3N6O3S
Molecular Weight
478.45
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Trpvicin
CAS Number2019994-90-0
PubChem CID122589101
IUPAC NameN-[5-[2-(2-cyanopropan-2-yl)-4-pyridinyl]-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxypyrimidine-5-carboxamide
Molecular FormulaC20H17F3N6O3S
Molecular Weight478.4
XLogP3.1
Topological Polar Surface Area151
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count12
Rotatable Bond Count6
Heavy Atom Count33
Formal Charge0
Complexity736
SMILES
CC(C)(C#N)C1=NC=CC(=C1)C2=C(N=C(S2)NC(=O)C3=C(N=CN=C3OC)OC)C(F)(F)F
InChI
InChI=1S/C20H17F3N6O3S/c1-19(2,8-24)11-7-10(5-6-25-11)13-14(20(21,22)23)28-18(33-13)29-15(30)12-16(31-3)26-9-27-17(12)32-4/h5-7,9H,1-4H3,(H,28,29,30)
InChIKey
CPIDEBBXBVMQOC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Trpvicin
CAS: 2019994-90-0
CID: 122589101
Formula: C20H17F3N6O3S
MW: 478.4
Interactive 3D Structure
Loading 3D structure...
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Computed Properties
PropertyValue
Molecular Weight478.4
XLogP33.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count12
Rotatable Bond Count6
Exact Mass478.10349409
Monoisotopic Mass478.10349409
Topological Polar Surface Area151 Ų
Heavy Atom Count33
Formal Charge0
Complexity736
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-165559-01Trpvicin

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